Open AccessGenetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene.
Author(s) -
Daniel S. Straus,
Walter Gilbert
Publication year - 1985
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.5.12.3497
Subject(s) - triosephosphate isomerase , biology , exon , gene , genetics , intron , sequence (biology) , microbiology and biotechnology
We report the sequence of the single chicken triosephosphate isomerase gene and its flanking regions. The 3-kilobase-long gene is composed of seven similarly sized exons and six introns. By using crystallographic and sequence data, we argue that this ancient gene was originally assembled from the genetic antecedents of exons.