Open AccessInterleukin 1 regulates human metallothionein gene expression.
Author(s) -
Michael Karin,
Richard J. Imbra,
Adriana Heguy,
Grace Wong
Publication year - 1985
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.5.10.2866
Subject(s) - metallothionein , biology , gene expression , scavenger , gene , microbiology and biotechnology , regulation of gene expression , radical , biochemistry
Incubation of cultured human cells with interleukin 1 leads to increased expression of the human metallothionein-IIA gene. Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.