Increased secretion of type beta transforming growth factor accompanies viral transformation of cells. | Zendy

Mario A. Anzano | Zendy; Anita B. Roberts | Zendy; Joseph E. De Larco | Zendy; Lalage M. Wakefield | Zendy; Richard K. Assoian | Zendy; N S Roche | Zendy; Joseph M. Smith | Zendy; Jacob E. Lazarus | Zendy; Michael B. Sporn | Zendy

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Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

Author(s) -

Mario A. Anzano,

Anita B. Roberts,

Joseph E. De Larco,

Lalage M. Wakefield,

Richard K. Assoian,

N S Roche,

Joseph M. Smith,

Jacob E. Lazarus,

Michael B. Sporn

Publication year - 1985

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.5.1.242

Subject(s) - biology , secretion , transforming growth factor beta , transforming growth factor , transformation (genetics) , transforming growth factor, beta 3 , microbiology and biotechnology , beta (programming language) , growth factor , receptor , virology , tgf alpha , genetics , endocrinology , gene , computer science , programming language

Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.

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