Open AccessActivity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.
Author(s) -
Minoru Morikawa,
H Green,
U J Lewis
Publication year - 1984
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.4.2.228
Subject(s) - biology , adipose tissue , effector , 3t3 l1 , hormone , 3t3 cells , microbiology and biotechnology , growth hormone , cell culture , human growth hormone , endocrinology , adipogenesis , transfection , genetics
A culture system is described for the study of cellular responsiveness to growth hormone. The hormone acts directly on an established line of preadipose 3T3 cells and promotes their differentiation into adipose cells. This response is the basis of a sensitive and specific assay and does not depend on the participation of an intermediate effector.