Identification of the Cloned Gene for the Murine Transplantation Antigen H-2Kbby Hybridization with Synthetic Oligonucleotides | Zendy

Dan H. Schulze | Zendy; Larry R. Pease | Zendy; Yuichi Obata | Zendy; Stanley G. Nathenson | Zendy; Antonio A. Reyes | Zendy; Satoshi Ikuta | Zendy; R. Bruce Wallace | Zendy

Open Access

Identification of the Cloned Gene for the Murine Transplantation Antigen H-2K^bby Hybridization with Synthetic Oligonucleotides

Author(s) -

Dan H. Schulze,

Larry R. Pease,

Yuichi Obata,

Stanley G. Nathenson,

Antonio A. Reyes,

Satoshi Ikuta,

R. Bruce Wallace

Publication year - 1983

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.3.4.750

Subject(s) - biology , complementary dna , oligonucleotide , microbiology and biotechnology , gene , major histocompatibility complex , clone (java method) , nucleic acid thermodynamics , dna , genetics , rna

The H-2K(b) gene is a member of the large major histocompatibility complex class I gene family. Since many members of this family cross-hybridize with class I cDNA probes, the cloned H-2K(b) gene was identified by hybridization with specific oligonucleotide probes. This clone was definitively shown to encode the H-2K(b) polypeptide by partial DNA sequencing and by serological and tryptic peptide analyses of the expressed product.

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