Open AccessFos Family Members Induce Cell Cycle Entry by Activating Cyclin D1
Author(s) -
Jennifer R. Brown,
Elizabeth A. Nigh,
Richard J. Lee,
Hong Ye,
Margaret A. Thompson,
Frédéric Saudou,
Richard G. Pestell,
Michael E. Greenberg
Publication year - 1998
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.18.9.5609
Subject(s) - cyclin d1 , biology , cyclin a , cell cycle , fosb , cyclin , cyclin d , cell growth , microbiology and biotechnology , transcription factor , cancer research , cell , genetics , gene
Expression of thefos family of transcription factors is stimulated by growth factors that induce quiescent cells to reenter the cell cycle, but the cellular targets of the Fos family that regulate cell cycle reentry have not been identified. To address this issue, mice that lack two members of thefos family, c-fos andfosB , were derived. ThefosB −/− c-fos −/− mice are similar in phenotype to c-fos −/− mice but are 30% smaller. This decrease in size is consistent with an abnormality in cell proliferation. Fibroblasts derived fromfosB −/− c-fos −/− mice were found to have a defect in proliferation that results at least in part from a failure to induce cyclin D1 following serum-stimulated cell cycle reentry. Although definitive evidence that c-Fos and FosB directly induce cyclin D1 transcription will require further analysis, these findings raise the possibility that c-Fos and FosB are either direct or indirect transcriptional regulators of the cyclin D1 gene and may function as a critical link between serum stimulation and cell cycle progression.