Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis | Zendy

Klaudia Götte | Zendy; Wolfgang Girzalsky | Zendy; Michael Linkert | Zendy; Evelyn Baumgart | Zendy; Stefan Kammerer | Zendy; WolfHubert Kunau | Zendy; Ralf Erdmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis

Author(s) -

Klaudia Götte,

Wolfgang Girzalsky,

Michael Linkert,

Evelyn Baumgart,

Stefan Kammerer,

WolfHubert Kunau,

Ralf Erdmann

Publication year - 1998

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.18.1.616

Subject(s) - prenylation , peroxisome , biology , biogenesis , biochemistry , peroxisomal targeting signal , cytosol , peptide sequence , microbiology and biotechnology , protein targeting , saccharomyces cerevisiae , immunoprecipitation , membrane protein , gene , enzyme , membrane

We report the identification and molecular characterization of Pex19p, an oleic acid-inducible, farnesylated protein of 39.7 kDa that is essential for peroxisome biogenesis in Saccharomyces cerevisiae. Cells lacking Pex19p are characterized by the absence of morphologically detectable peroxisomes and mislocalization of peroxisomal matrix proteins to the cytosol. The human HK33 gene product was identified as the putative human ortholog of Pex19p. Evidence is provided that farnesylation of Pex19p takes place at the cysteine of the C-terminal CKQQ amino acid sequence. Farnesylation of Pex19p was shown to be essential for the proper function of the protein in peroxisome biogenesis. Pex19p was shown to interact with Pex3p in vivo, and this interaction required farnesylation of Pex19p.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research