A Circadian Enhancer Mediates PER-Dependent mRNA Cycling in Drosophila melanogaster | Zendy

Haiping Hao | Zendy; David L. Allen | Zendy; Paul E. Hardin | Zendy

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A Circadian Enhancer Mediates PER-Dependent mRNA Cycling in Drosophila melanogaster

Author(s) -

Haiping Hao,

David L. Allen,

Paul E. Hardin

Publication year - 1997

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.17.7.3687

Subject(s) - biology , enhancer , drosophila melanogaster , circadian clock , circadian rhythm , transcription (linguistics) , genetics , gene , clock , gene expression , melanogaster , messenger rna , microbiology and biotechnology , endocrinology , linguistics , philosophy

Genes expressed under circadian-clock control are found in organisms ranging from prokaryotes to humans. In Drosophila melanogaster, the period (per) gene, which is required for clock function, is transcribed in a circadian manner. We have identified a circadian transcriptional enhancer within a 69-bp DNA fragment upstream of the per gene. This enhancer drives high-amplitude mRNA cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (PER) dependent. An E-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that PER mediates circadian transcription through other sequences in this fragment.

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