Interaction of Vav with ENX-1, a Putative Transcriptional Regulator of Homeobox Gene Expression | Zendy

Oliver Hobert | Zendy; Bahija Jallal | Zendy; Axel Ullrich | Zendy

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Interaction of Vav with ENX-1, a Putative Transcriptional Regulator of Homeobox Gene Expression

Author(s) -

Oliver Hobert,

Bahija Jallal,

Axel Ullrich

Publication year - 1996

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.16.6.3066

Subject(s) - biology , homeobox , enhancer , gene , regulation of gene expression , regulator , transcriptional regulation , genetics , transcription factor , gene product , effector , microbiology and biotechnology , gene expression

The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.

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