Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. | Zendy

E C Park | Zendy; J W Szostak | Zendy

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Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

Author(s) -

E C Park,

J W Szostak

Publication year - 1990

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.10.9.4932

Subject(s) - biology , derepression , genetics , locus (genetics) , histone h4 , mating type , histone , serine , mating of yeast , gene , microbiology and biotechnology , gene expression , psychological repression , phosphorylation

The N-terminal serine and four conserved lysine residues near the N-terminus of yeast histone H4 are acetylated. We found that a mutation that changed the fourth lysine to alanine resulted in specific derepression of the silent mating type locus HML, while mutations that altered the N-terminal serine or the first three lysines had only minor phenotypic effects. Our results support an active role for histone H4 in the silencing of gene expression at this locus.

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