Open AccessThe cytomegalovirus enhancer: a pan-active control element in transgenic mice.
Author(s) -
Emmett V. Schmidt,
Grunau Christoph,
Rolf Zeller,
Philip Leder
Publication year - 1990
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.10.8.4406
Subject(s) - enhancer , biology , transgene , genetically modified mouse , cytomegalovirus , microbiology and biotechnology , kidney , regulatory sequence , gene expression , virology , gene , virus , genetics , herpesviridae , viral disease
In an effort to identify widely active positive regulatory elements, we have examined the action of the cytomegalovirus enhancer-promoter in transgenic mice. These elements activated expression in 24 of 28 tissues tested. The greatest expression was observed in the heart, kidney, brain, and testis. Maximum expression further localized to specific cells within the heart and kidney.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom