bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation. | Zendy

Alan Engelman | Zendy; Naomi Rosenberg | Zendy

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bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.

Author(s) -

Alan Engelman,

Naomi Rosenberg

Publication year - 1990

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.10.8.4365

Subject(s) - biology , abl , proto oncogene tyrosine protein kinase src , cancer research , transformation (genetics) , breakpoint cluster region , microbiology and biotechnology , virology , signal transduction , tyrosine kinase , receptor , gene , genetics

Lymphoid cells transformed by temperature-sensitive Abelson virus die at the nonpermissive temperature. This property was exploited to show that bcr/abl and v-src but not myc and ras can replace the transforming signal of v-abl, a result suggesting that the former but not the latter oncogenes transform lymphoid cells via a similar pathway.

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