Open Accessbcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.
Author(s) -
Alan Engelman,
Naomi Rosenberg
Publication year - 1990
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.10.8.4365
Subject(s) - biology , abl , proto oncogene tyrosine protein kinase src , cancer research , transformation (genetics) , breakpoint cluster region , microbiology and biotechnology , virology , signal transduction , tyrosine kinase , receptor , gene , genetics
Lymphoid cells transformed by temperature-sensitive Abelson virus die at the nonpermissive temperature. This property was exploited to show that bcr/abl and v-src but not myc and ras can replace the transforming signal of v-abl, a result suggesting that the former but not the latter oncogenes transform lymphoid cells via a similar pathway.