Open AccessIdentification of an octamer-binding site in the human kappa light-chain enhancer.
Author(s) -
Keats Nelms,
Brian Van Ness
Publication year - 1990
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.10.7.3843
Subject(s) - enhancer , histone octamer , biology , immunoglobulin light chain , enhancer rnas , gene , promoter , binding site , microbiology and biotechnology , immunoglobulin heavy chain , genetics , transcription factor , antibody , gene expression , histone , nucleosome
Octamer motifs contribute to the function and tissue specificity of immunoglobulin heavy- and light-chain gene promoters and the heavy-chain enhancer. A variant octamer-binding site within a conserved region of the human kappa light-chain gene enhancer which contributes to the function of this enhancer has been identified.