Open AccessFunctional analysis of a duplicated linked pair of ribosomal protein genes in Saccharomyces cerevisiae.
Author(s) -
David M. Donovan,
Mary P. Remington,
David A. Stewart,
J C Crouse,
David J. C. Miles,
Nancy J. Pearson
Publication year - 1990
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.10.11.6097
Subject(s) - biology , gene , genetics , saccharomyces cerevisiae , ribosomal protein , genome , ribosomal rna , ribosome , rna
Ribosomal protein genes RP28 and S16A (RP55) are closely linked. Another set of this pair of genes exists in the genome (copy 2), genetically unlinked to copy 1. By using gene replacement techniques, we have shown that RP28 from copy 1 is required for vegetative growth and that the cells need S16A from copy 2 to achieve maximum growth rate.