FACT and the H2B N Tail | Zendy

Mary Ann Osley | Zendy

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FACT and the H2B N Tail

Author(s) -

Mary Ann Osley

Publication year - 2013

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.01519-13

Subject(s) - nucleosome , biology , chromatosome , histone , promoter , histone h2b , microbiology and biotechnology , transcription (linguistics) , transcription factor , linker dna , histone code , genetics , dna , gene , gene expression , linguistics , philosophy

The FACT histone chaperone/nucleosome reorganization factor plays key roles in nucleosome dynamics during transcription. A new study has linked a specific domain in the H2B N terminus to the activity of FACT in regulating nucleosome disassembly at promoters during transcription activation and nucleosome reassembly at coding regions during transcription elongation.

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