Articles of Significant Interest Selected from This Issue by the Editors

Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) are homologous scaffolds that coordinate and promote extracellular signalregulated kinase (ERK) signaling with different physiological outcomes. KSR2 influences energy expenditure and adiposity, while KSR1 is dispensable for normal development but critical for tumor formation by oncogenic Ras. Fernandez et al. (p. 3718 –3731) demonstrate that in tumor cells, KSR2 coordinates aerobic glycolysis and oxidative phosphorylation with tumor cell proliferation and transformation. However, the metabolic effects mediated by KSR2 are dependent upon AMPK signaling and independent of its ERK1/2 scaffolding function.