Article of Significant Interest Selected from This Issue by the Editors

RvErp, Mycobacterium tuberculosis exported repetitive protein, is an important virulence factor. Using a yeast two-hybrid assay, Ganaie et al. (p. 2841–2852) identified Rv2212, an adenylyl cyclase, as a novel interacting partner of RvErp. This study reveals the divergence between M. tuberculosis and Mycobacterium smegmatis in the relationship of RvErp and Rv2212 proteins, as this interaction is observed only for the M. tuberculosis proteins, and thus adds an important but distinct dimension to the role of RvErp in intracellular virulence. This work opens the field for the discovery of unexplored roles of RvErp.