Role of Deubiquitinating Enzymes in DNA Repair | Zendy

Younghoon Kee | Zendy; Tony T. Huang | Zendy

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Role of Deubiquitinating Enzymes in DNA Repair

Author(s) -

Younghoon Kee,

Tony T. Huang

Publication year - 2015

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00847-15

Subject(s) - deubiquitinating enzyme , biology , dna repair , dna damage , ubiquitin , dna , microbiology and biotechnology , genetics , gene

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.

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