Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive | Zendy

Sweta Mishra | Zendy; Johnathan R. Whetstine | Zendy

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Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive

Author(s) -

Sweta Mishra,

Johnathan R. Whetstine

Publication year - 2016

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00652-15

Subject(s) - biology , copy number variation , mechanism (biology) , gene dosage , transient (computer programming) , computational biology , genetics , gene , genome , computer science , philosophy , gene expression , epistemology , operating system

Chromosomal copy number changes are frequently associated with harmful consequences and are thought of as an underlying mechanism for the development of diseases. However, changes in copy number are observed during development and occur during normal biological processes. In this review, we highlight the causes and consequences of copy number changes in normal physiologic processes as well as cover their associations with cancer and acquired drug resistance. We discuss the permanent and transient nature of copy number gains and relate these observations to a new mechanism driving transient site-specific copy gains (TSSGs). Finally, we discuss implications of TSSGs in generating intratumoral heterogeneity and tumor evolution and how TSSGs can influence the therapeutic response in cancer.

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