Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis
Author(s) -
Anuj,
Lakshmi Arivazhagan,
Ganesh Venkatraman,
Suresh K. Rayala
Publication year - 2019
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00577-18
Subject(s) - biology , cancer research , microrna , focal adhesion , chromatin immunoprecipitation , breast cancer , carcinogenesis , breast carcinoma , metastasis , luciferase , untranslated region , cancer , three prime untranslated region , signal transduction , microbiology and biotechnology , promoter , gene expression , messenger rna , transfection , cell culture , gene , genetics
Breast cancer is a recurrent type of cancer among women worldwide. Despite remarkable progress in the prevention, detection, and treatment of breast cancer, it still remains a major chronic problem worldwide and poses significant challenges, like metastasis to distant organs, demanding the need for novel biomarkers and therapeutic targets.
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