Open AccessHypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression
Author(s) -
Stephanie Muenchau,
Rosalie Deutsch,
Inês J. de Castro,
Thomas Hielscher,
Nora Heber,
Beate Niesler,
Marina Lušić,
Megan L. Stanifer,
Steeve Boulant
Publication year - 2019
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00553-18
Subject(s) - barrier function , microbiology and biotechnology , microrna , biology , regulator , gene silencing , gene knockdown , homeostasis , hypoxia (environmental) , intestinal mucosa , regulation of gene expression , tight junction , cell culture , oxygen , chemistry , biochemistry , gene , genetics , medicine , organic chemistry
Intestinal epithelial cells (IECs) are exposed to the low-oxygen environment present in the lumen of the gut. These hypoxic conditions on one hand are fundamental for the survival of the commensal microbiota and, on the other hand, favor the formation of a selective semipermeable barrier, allowing IECs to transport essential nutrients/water while keeping the sterile internal compartments separated from the lumen containing commensals.
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