Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export | Zendy

Rwik Sen | Zendy; Priyanka Barman | Zendy; Amala Kaja | Zendy; Jannatul Ferdoush | Zendy; Shweta Lahudkar | Zendy; Arpan Datta Roy | Zendy; Sukesh R. Bhaumik | Zendy

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Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export

Author(s) -

Rwik Sen,

Priyanka Barman,

Amala Kaja,

Jannatul Ferdoush,

Shweta Lahudkar,

Arpan Datta Roy,

Sukesh R. Bhaumik

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00540-18

Subject(s) - biology , messenger rna , nuclear export signal , rna splicing , polyadenylation , microbiology and biotechnology , precursor mrna , saccharomyces cerevisiae , transcription (linguistics) , gene , rna , cell nucleus , genetics , nucleus , linguistics , philosophy

Cap-binding complex (CBC) associates cotranscriptionally with the cap structure at the 5′ end of nascent mRNA to protect it from exonucleolytic degradation. Here, we show that CBC promotes the targeting of an mRNA export adaptor, Yra1 (forming transcription export [TREX] complex with THO and Sub2), to the active genes and enhances mRNA export inSaccharomyces cerevisiae .

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