IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism | Zendy

Laura Regué | Zendy; Fei Ji | Zendy; Daniel Flicker | Zendy; Dana Krämer | Zendy; William M. Pierce | Zendy; Teekhon Davidoff | Zendy; Jeffrey J. Widrick | Zendy; Nicholas Houstis | Zendy; Liliana Minichiello | Zendy; Ning Dai | Zendy; Joseph Avruch | Zendy

Open Access

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism

Author(s) -

Laura Regué,

Fei Ji,

Daniel Flicker,

Dana Krämer,

William M. Pierce,

Teekhon Davidoff,

Jeffrey J. Widrick,

Nicholas Houstis,

Liliana Minichiello,

Ning Dai,

Joseph Avruch

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00528-18

Subject(s) - medicine , endocrinology , biology , skeletal muscle , insulin like growth factor 1 receptor , autocrine signalling , growth factor , protein turnover , carbohydrate metabolism , insulin , beta oxidation , metabolism , receptor , protein biosynthesis , biochemistry

Insulin-like growth factor 2 (IGF2) mRNA binding protein 2 (IMP2) was selectively deleted from adult mouse muscle; two phenotypes were observed: decreased accrual of skeletal muscle mass after weaning and reduced wheel-running activity but normal forced treadmill performance. Reduced wheel running occurs when mice are fed a high-fat diet but is normalized when mice consume standard chow.

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