Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models | Zendy

Mathilde Soulez | Zendy; Marc K. Saba-El-Leil | Zendy; Benjamin Turgeon | Zendy; Simon Mathien | Zendy; Philippe Coulombe | Zendy; Sonia Klinger | Zendy; Justine Rousseau | Zendy; Kim Lévesque | Zendy; Sylvain Meloche | Zendy

Open Access

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models

Author(s) -

Mathilde Soulez,

Marc K. Saba-El-Leil,

Benjamin Turgeon,

Simon Mathien,

Philippe Coulombe,

Sonia Klinger,

Justine Rousseau,

Kim Lévesque,

Sylvain Meloche

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00527-18

Subject(s) - biology , genetically engineered , extracellular , microbiology and biotechnology , genetically modified organism , signal transduction , kinase , genetics , gene

The physiological functions of the atypical mitogen-activated protein kinase extracellular signal-regulated kinase 3 (ERK3) remain poorly characterized. Previous analysis of mice with a targeted insertion of thelacZ reporter in theMapk6 locus (Mapk6lacZ ) showed that inactivation of ERK3 inMapk6lacZ mice leads to perinatal lethality associated with intrauterine growth restriction, defective lung maturation, and neuromuscular anomalies.

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