Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance | Zendy

Jessica Tsalikis | Zendy; Mena AbdelNour | Zendy; Armin Farahvash | Zendy; Matthew T. Sorbara | Zendy; Stephanie Poon | Zendy; Dana J. Philpott | Zendy; Stephen E. Girardin | Zendy

Open Access

Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance

Author(s) -

Jessica Tsalikis,

Mena AbdelNour,

Armin Farahvash,

Matthew T. Sorbara,

Stephanie Poon,

Dana J. Philpott,

Stephen E. Girardin

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00489-18

Subject(s) - proteasome , microbiology and biotechnology , biology , autophagy , protein degradation , programmed cell death , proteasome inhibitor , endoplasmic reticulum associated protein degradation , bortezomib , tfeb , apoptosis , unfolded protein response , endoplasmic reticulum , lysosome , biochemistry , immunology , multiple myeloma , enzyme

Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these catabolic processes. We report here that isoginkgetin, a naturally derived biflavonoid, sensitized cells undergoing nutrient starvation to apoptosis, induced lysosomal stress, and activated the lysosome biogenesis geneTFEB .

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