E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair | Zendy

Clare C. So | Zendy; Shaliny Ramachandran | Zendy; Alberto Martín | Zendy

Open Access

E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair

Author(s) -

Clare C. So,

Shaliny Ramachandran,

Alberto Martín

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00488-18

Subject(s) - biology , histone h2b , h3k4me3 , microbiology and biotechnology , ubiquitin , dna repair , histone , non homologous end joining , homologous recombination , ubiquitin ligase , dna damage , sumo protein , dna , genetics , gene , promoter , gene expression

Histone posttranslational modifications play fundamental roles in the regulation of double-stranded DNA break (DSB) repair. RNF20/RNF40-mediated monoubiquitination of histone H2B on lysine 120 (H2Bub) has been suggested as a potential mediator of DSB repair, although the nature and function of this posttranslational modification remain enigmatic.

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