Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis | Zendy

Himangshu S. Bose | Zendy; Fadi Gebrail | Zendy; Brendan Marshall | Zendy; Elizabeth W. Perry | Zendy; Randy M. Whittal | Zendy

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Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis

Author(s) -

Himangshu S. Bose,

Fadi Gebrail,

Brendan Marshall,

Elizabeth W. Perry,

Randy M. Whittal

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00484-18

Subject(s) - biology , translocase , inner mitochondrial membrane , mitochondrial matrix , pregnenolone , mitochondrion , biochemistry , cholesterol side chain cleavage enzyme , microbiology and biotechnology , steroid biosynthesis , mitochondrial carrier , atp–adp translocase , dnaja3 , mitochondrial fusion , steroid , enzyme , cytochrome p450 , cytosol , mitochondrial dna , bacterial outer membrane , gene , chromosomal translocation , escherichia coli , hormone

Adrenal and gonadal mitochondrial metabolic activity requires electrons from cofactors, cholesterol, and a substrate for rapid steroid synthesis, an essential requirement for mammalian survival. Substrate activity depends on its environment, which is regulated by chaperones and mitochondrial translocases.

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