Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes | Zendy

Urmila Sehrawat | Zendy; Femke Koning | Zendy; Shaked Ashkenazi | Zendy; Gil Stelzer | Zendy; Dena Leshkowitz | Zendy; Rivka Dikstein | Zendy

Open Access

Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

Author(s) -

Urmila Sehrawat,

Femke Koning,

Shaked Ashkenazi,

Gil Stelzer,

Dena Leshkowitz,

Rivka Dikstein

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00441-18

Subject(s) - biology , cell cycle , microbiology and biotechnology , untranslated region , mutant , initiation factor , gene knockdown , genetics , gene , translation (biology) , messenger rna

Protein synthesis is linked to cell proliferation, and its deregulation contributes to cancer. Eukaryotic translation initiation factor 1A (eIF1A) plays a key role in scanning and AUG selection and differentially affects the translation of distinct mRNAs.

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