Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding | Zendy

Lia Kallenberger | Zendy; Rachel Erb | Zendy; Lucie Kralickova | Zendy; Andrea Patrignani | Zendy; Esther Stöckli | Zendy; Josef Jiricny | Zendy

Open Access

Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding

Author(s) -

Lia Kallenberger,

Rachel Erb,

Lucie Kralickova,

Andrea Patrignani,

Esther Stöckli,

Josef Jiricny

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00436-19

Subject(s) - biology , microbiology and biotechnology , enhancer , epigenetics of physical exercise , promoter , dna methylation , reporter gene , cpg site , methylation , tata box , hypersensitive site , vitellogenin , transcription factor , gene , gene expression , genetics

The enhancer/promoter of the vitellogenin II gene (VTG ) has been extensively studied as a model system of vertebrate transcriptional control. While deletion mutagenesis andin vivo footprinting identified the transcription factor (TF) binding sites governing its tissue specificity, DNase hypersensitivity and DNA methylation studies revealed the epigenetic changes accompanying its hormone-dependent activation.

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