The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2 | Zendy

Kyle T. Helzer | Zendy; Mary Szatkowski Ozers | Zendy; Mark B. Meyer | Zendy; Nancy A. Benkusky | Zendy; Natalia Solodin | Zendy; Rebecca Reese | Zendy; Christopher L. Warren | Zendy; J. Wesley Pike | Zendy; Elaine T. Alarid | Zendy

Open Access

The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2

Author(s) -

Kyle T. Helzer,

Mary Szatkowski Ozers,

Mark B. Meyer,

Nancy A. Benkusky,

Natalia Solodin,

Rebecca Reese,

Christopher L. Warren,

J. Wesley Pike,

Elaine T. Alarid

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00417-18

Subject(s) - enhancer , biology , chromatin immunoprecipitation , transcription factor , estrogen receptor alpha , estrogen receptor , chromatin , phosphorylation , hormone response element , enhancer rnas , estrogen receptor beta , microbiology and biotechnology , binding site , promoter , pioneer factor , dna , gene , biochemistry , genetics , gene expression , cancer , breast cancer

Posttranslational modifications are key regulators of protein function, providing cues that can alter protein interactions and cellular location. Phosphorylation of estrogen receptor α (ER) at serine 118 (pS118-ER) occurs in response to multiple stimuli and is involved in modulating ER-dependent gene transcription.

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