A Feedback Loop between MicroRNA 155 (miR-155), Programmed Cell Death 4, and Activation Protein 1 Modulates the Expression of miR-155 and Tumorigenesis in Tongue Cancer | Zendy

Shabir A. Zargar | Zendy; Vivek Singh Tomar | Zendy; Vidyarani Shyamsundar | Zendy; Vijayalakshmi Ramshankar | Zendy; Kumaravel Somasundaram | Zendy; Devarajan Karunagaran | Zendy

Open Access

A Feedback Loop between MicroRNA 155 (miR-155), Programmed Cell Death 4, and Activation Protein 1 Modulates the Expression of miR-155 and Tumorigenesis in Tongue Cancer

Author(s) -

Shabir A. Zargar,

Vivek Singh Tomar,

Vidyarani Shyamsundar,

Vijayalakshmi Ramshankar,

Kumaravel Somasundaram,

Devarajan Karunagaran

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00410-18

Subject(s) - biology , gene knockdown , carcinogenesis , ectopic expression , microrna , mir 155 , microbiology and biotechnology , cancer research , apoptosis , cancer , cell culture , gene , genetics

MicroRNA 155 (miR-155) is an oncomir, generated as a noncoding RNA from theBIC gene whose promoter activity is mainly controlled via activation protein 1 (AP-1) and NF-κB transcription factors. We found that the expression levels of miR-155 and programmed cell death 4 (Pdcd4) exhibit inverse relationships in tongue cancer cells (SAS and AWL) and tumor tissues compared to their relationships in normal FBM cells and normal tongue tissues, respectively.

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