Open AccessNovel Lines of Evidence for the Asymmetric Strand Displacement Model of Mitochondrial DNA Replication
Author(s) -
ChihLin Hsieh
Publication year - 2018
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00406-18
Subject(s) - biology , mitochondrial dna , heavy strand , dna replication , genome , dna , genetics , origin of replication , microbiology and biotechnology , dnag , eukaryotic dna replication , gene , rna , transfer rna
The mitochondrial genome, which consists of 16,569 bp of DNA with a cytosine-rich light (L) strand and a heavy (H) strand, exists as a multicopy closed circular genome within the mitochondrial matrix. The machinery for replication of the mammalian mitochondrial genome is distinct from that for replication of the nuclear genome.
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