Open AccessNuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes
Author(s) -
Igor Cestari,
Hilary McLeland-Wieser,
Kenneth Stuart
Publication year - 2018
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00395-18
Subject(s) - biology , gene , subtelomere , telomere binding protein , genetics , microbiology and biotechnology , telomere , dna binding protein , transcription factor
Allelic exclusion of variant surface glycoprotein (VSG) genes is essential for African trypanosomes to evade the host antibody response by antigenic variation. The mechanisms by which this parasite expresses only one of its ∼2,000 VSG genes at a time are unknown.
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