The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways | Zendy

Wonkyoung Cho | Zendy; Xiongjie Jin | Zendy; Junfeng Pang | Zendy; Yan Wang | Zendy; Nahid F. Mivechi | Zendy; Demetrius Moskophidis | Zendy

Open Access

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways

Author(s) -

Wonkyoung Cho,

Xiongjie Jin,

Junfeng Pang,

Yan Wang,

Nahid F. Mivechi,

Demetrius Moskophidis

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00391-18

Subject(s) - biology , protein kinase a , cancer research , microbiology and biotechnology , signal transduction , mapk/erk pathway , heat shock protein , kinase , tumor progression , malignant transformation , cancer , genetics , gene

Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of diagnostic and preventive strategies. Heat shock protein 70 (HSP70) acts in concert with several cochaperones and nucleotide exchange factors and plays an essential role in protein quality control that increases survival by protecting cells against environmental stressors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research