Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis | Zendy

Ranjula Wijayatunge | Zendy; Sam R. Holmstrom | Zendy; Samantha B. Foley | Zendy; Victoria Mgbemena | Zendy; Varsha Bhargava | Zendy; Gerardo López Pérez | Zendy; Kelly McCrum | Zendy; Theodora S. Ross | Zendy

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Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis

Author(s) -

Ranjula Wijayatunge,

Sam R. Holmstrom,

Samantha B. Foley,

Victoria Mgbemena,

Varsha Bhargava,

Gerardo López Pérez,

Kelly McCrum,

Theodora S. Ross

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00385-18

Subject(s) - biology , phenotype , phosphocholine , gene expression , knockout mouse , microbiology and biotechnology , gene , genetics , phospholipid , membrane , phosphatidylcholine

Deficiency of huntingtin-interacting protein 1 (Hip1) results in degenerative phenotypes. Here we generated aHip1 deficiency allele where a floxed transcriptional stop cassette and a humanHIP1 cDNA were knocked into intron 1 of the mouseHip1 locus.

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