Open AccessMutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Author(s) -
Leixiang Yang,
Tanjing Song,
Qian Cheng,
Lihong Chen,
Jiandong Chen
Publication year - 2018
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00375-18
Subject(s) - mutant , mdm2 , ubiquitin ligase , ubiquitin , biology , dna ligase , wild type , microbiology and biotechnology , biochemistry , enzyme , gene
Missense p53 mutants often accumulate in tumors and drive progression through gain of function. MDM2 efficiently degrades wild-type p53 but fails to degrade mutant p53 in tumor cells.
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