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Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout mouse model,Smpd3flox/flox ;Osx-Cre mice, in whichSmpd3 was ablated inOsx -expressing chondrocytes and osteoblasts during early skeletogenesis.

Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression