Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression | Zendy

Garthiga Manickam | Zendy; Pierre Moffatt | Zendy; Monzur Murshed | Zendy

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Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression

Author(s) -

Garthiga Manickam,

Pierre Moffatt,

Monzur Murshed

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00370-18

Subject(s) - biology , bone healing , expression (computer science) , microbiology and biotechnology , bioinformatics , computational biology , genetics , programming language , computer science

Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout mouse model,Smpd3flox/flox ;Osx-Cre mice, in whichSmpd3 was ablated inOsx -expressing chondrocytes and osteoblasts during early skeletogenesis.

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