Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts | Zendy

Huda H. AlKhalaf | Zendy; Hazem Ghebeh | Zendy; Rabia Inass | Zendy; Abdelilah Aboussekhra | Zendy

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Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts

Author(s) -

Huda H. AlKhalaf,

Hazem Ghebeh,

Rabia Inass,

Abdelilah Aboussekhra

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00359-18

Subject(s) - stromal cell , paracrine signalling , biology , senescence , cancer research , microbiology and biotechnology , carcinogenesis , cancer associated fibroblasts , mesenchymal stem cell , fibroblast , tumor microenvironment , in vitro , cancer , biochemistry , genetics , receptor , tumor cells

Aging and stress promote senescence, which has intrinsic tumor suppressor functions and extrinsic tumor promoting properties. Therefore, it is of utmost importance to delineate the effects of senescence inducers on the various types of cells that compose the different organs.

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