APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction | Zendy

Daniel J. Salamango | Zendy; Jordan T. Becker | Zendy; Jennifer L. McCann | Zendy; Adam Z. Cheng | Zendy; Özlem Demir | Zendy; Rommie E. Amaro | Zendy; William L. Brown | Zendy; Nadine M. Shaban | Zendy; Reuben S. Harris | Zendy

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APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

Author(s) -

Daniel J. Salamango,

Jordan T. Becker,

Jennifer L. McCann,

Adam Z. Cheng,

Özlem Demir,

Rommie E. Amaro,

William L. Brown,

Nadine M. Shaban,

Reuben S. Harris

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00356-18

Subject(s) - biology , subcellular localization , cytoplasm , nucleolus , dna , nuclear localization sequence , cell nucleus , mutagenesis , microbiology and biotechnology , cytosol , restriction enzyme , nuclear export signal , genetics , enzyme , mutation , biochemistry , gene

APOBEC enzymes are DNA cytosine deaminases that normally serve as virus restriction factors, but several members, including APOBEC3H, also contribute to cancer mutagenesis. Despite their importance in multiple fields, little is known about cellular processes that regulate these DNA mutating enzymes.

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