ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation | Zendy

Zhuojuan Luo | Zendy; Xiaoxu Liu | Zendy; Hao Xie | Zendy; Yan Wang | Zendy; Chengqi Lin | Zendy

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ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation

Author(s) -

Zhuojuan Luo,

Xiaoxu Liu,

Hao Xie,

Yan Wang,

Chengqi Lin

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00329-19

Subject(s) - biology , promoter , rna polymerase ii , chromatin , transcription factor , transcription (linguistics) , microbiology and biotechnology , transcriptional regulation , gene , chromatin immunoprecipitation , genetics , gene expression , linguistics , philosophy

The roles of the MYC transcription factor in transcriptional regulation have been studied intensively. However, the general mechanism underlying the recruitment of MYC to chromatin is less clear. Here, we found that the Krüppel-like transcription factor ZFP281 plays important roles in recruiting MYC to active promoters in mouse embryonic stem cells.

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