Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells | Zendy

Fumiki Katsuoka | Zendy; Akihito Otsuki | Zendy; Mizue Takahashi | Zendy; Shin Ito | Zendy; Masayuki Yamamoto | Zendy

Open Access

Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells

Author(s) -

Fumiki Katsuoka,

Akihito Otsuki,

Mizue Takahashi,

Shin Ito,

Masayuki Yamamoto

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00273-19

Subject(s) - biology , activator (genetics) , gene , repressor , protein subunit , microbiology and biotechnology , transcription factor , genetics

A group of cytoprotective genes is regulated by heterodimers composed of the cap’n’collar (CNC) family member Nrf2 and one of the small Maf (sMaf) proteins (MafF, MafG, or MafK) through the antioxidant response element (ARE, also referred to as the CNC-sMaf binding element [CsMBE]). Many lines of evidence support this model; however, a direct and specific evaluation of the Nrf2-sMaf heterodimer remains to be executed.

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