Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation | Zendy

Lluís Morey | Zendy; Alexandra Santanach | Zendy; Luciano Di Croce | Zendy

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Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation

Author(s) -

Lluís Morey,

Alexandra Santanach,

Luciano Di Croce

Publication year - 2015

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00266-15

Subject(s) - biology , epigenetics , embryonic stem cell , stem cell , cellular differentiation , regenerative medicine , microbiology and biotechnology , cell fate determination , cell potency , epigenesis , polycomb group proteins , computational biology , induced pluripotent stem cell , genetics , dna methylation , transcription factor , gene , gene expression , repressor

Embryonic stem cells (ESCs) are characterized by their ability to self-renew and to differentiate into all cell types of a given organism. Understanding the molecular mechanisms that govern the ESC state is of great interest not only for basic research-for instance, ESCs represent a perfect system to study cellular differentiation in vitro-but also for their potential implications in human health, as these mechanisms are likewise involved in cancer progression and could be exploited in regenerative medicine. In this minireview, we focus on the latest insights into the molecular mechanisms mediated by the pluripotency factors as well as their roles during differentiation. We also discuss recent advances in understanding the function of the epigenetic regulators, Polycomb and MLL complexes, in ESC biology.

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