Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway | Zendy

Xiaohui Zhang | Zendy; Pin Jin Hu | Zendy; Yangqin Xie | Zendy; YongJun Kang | Zendy; Min Li | Zendy

Open Access

Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

Author(s) -

Xiaohui Zhang,

Pin Jin Hu,

Yangqin Xie,

YongJun Kang,

Min Li

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00251-19

Subject(s) - biology , pten , hotair , protein kinase b , cancer research , signal transduction , long non coding rna , microbiology and biotechnology , kinase , phosphatidylinositol , pi3k/akt/mtor pathway , rna , genetics , gene

Accumulating evidence has demonstrated that long noncoding RNAs (lncRNAs) exert essential biological functions in modulating the progression of endometrial carcinoma (EC). HOX transcript antisense intergenetic RNA (HOTAIR) has been widely recognized as a crucial mediator in various tumors, including EC. However, the specific molecular mechanism of HOTAIR in the development of EC remains to be further explored.

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