CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers | Zendy

Sam Van de Velde | Zendy; Ezra Wiater | Zendy; Melissa Tran | Zendy; Yousang Hwang | Zendy; Philip A. Cole | Zendy; Marc Montminy | Zendy

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CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers

Author(s) -

Sam Van de Velde,

Ezra Wiater,

Melissa Tran,

Yousang Hwang,

Philip A. Cole,

Marc Montminy

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00200-19

Subject(s) - creb , enhancer , biology , gene expression , regulation of gene expression , chromatin , creb binding protein , p300 cbp transcription factors , histone , microbiology and biotechnology , gene , transcription factor , genetics , histone acetyltransferases

CREB mediates effects of cyclic AMP on cellular gene expression. Ubiquitous CREB target genes are induced following recruitment of CREB and its coactivators to promoter proximal binding sites. We found that CREB stimulates the expression of pancreatic beta cell-specific genes by targeting CBP/p300 to promoter-distal enhancer regions.

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