Heat Shock Causes a Reversible Increase in RNA Polymerase II Occupancy Downstream of mRNA Genes, Consistent with a Global Loss in Transcriptional Termination | Zendy

Joseph F. Cardiello | Zendy; James A. Goodrich | Zendy; Jennifer F. Kugel | Zendy

Open Access

Heat Shock Causes a Reversible Increase in RNA Polymerase II Occupancy Downstream of mRNA Genes, Consistent with a Global Loss in Transcriptional Termination

Author(s) -

Joseph F. Cardiello,

James A. Goodrich,

Jennifer F. Kugel

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00181-18

Subject(s) - biology , psychological repression , rna polymerase ii , heat shock , gene , transcription (linguistics) , occupancy , microbiology and biotechnology , gene expression , polymerase , transcriptional regulation , messenger rna , heat shock factor , heat shock protein , rna polymerase , rna , genetics , promoter , hsp70 , ecology , linguistics , philosophy

Cellular transcriptional programs are tightly controlled but can profoundly change in response to environmental challenges or stress. Here we describe global changes in mammalian RNA polymerase II (Pol II) occupancy at mRNA genes in response to heat shock and after recovery from the stress.

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