Open AccessRas Suppresses TXNIP Expression by Restricting Ribosome Translocation
Author(s) -
Zhizhou Ye,
Donald E. Ayer
Publication year - 2018
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00178-18
Subject(s) - txnip , biology , microbiology and biotechnology , protein biosynthesis , messenger rna , transcription (linguistics) , translation (biology) , thioredoxin interacting protein , downregulation and upregulation , biochemistry , gene , thioredoxin , linguistics , philosophy
Oncogenic Ras upregulates aerobic glycolysis to meet the bioenergetic and biosynthetic demands of rapidly growing cells. In contrast, thioredoxin-interacting protein (TXNIP) is a potent inhibitor of glucose uptake and is frequently downregulated in human cancers.
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