A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast | Zendy

Yong-jie Xu | Zendy; Saman Khan | Zendy; Adam C. Didier | Zendy; Michał Woźniak | Zendy; Yufeng Liu | Zendy; Amanpreet Singh | Zendy; Toru Nakamura | Zendy

Open Access

A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3^ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast

Author(s) -

Yong-jie Xu,

Saman Khan,

Adam C. Didier,

Michał Woźniak,

Yufeng Liu,

Amanpreet Singh,

Toru Nakamura

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00175-19

Subject(s) - biology , g2 m dna damage checkpoint , mutant , checkpoint kinase 2 , kinase , mutation , dna replication , genetics , microbiology and biotechnology , dna damage , dna , cell cycle checkpoint , cell cycle , protein kinase a , gene , protein serine threonine kinases

In response to perturbed DNA replication, ATR (ataxia telangiectasia and Rad3-related) kinase is activated to initiate the checkpoint signaling necessary for maintaining genome integrity and cell survival. To better understand the signaling mechanism, we carried out a large-scale genetic screen in fission yeast looking for mutants with enhanced sensitivity to hydroxyurea.

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