Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript | Zendy

Louis R. Ghanem | Zendy; Andrew Kromer | Zendy; Ian M. Silverman | Zendy; Xinjun Ji | Zendy; Matthew R. Gazzara | Zendy; Nhu Nguyen | Zendy; Gabrielle Aguilar | Zendy; Massimo Martinelli | Zendy; Yoseph Barash | Zendy; Stephen A. Liebhaber | Zendy

Open Access

Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript

Author(s) -

Louis R. Ghanem,

Andrew Kromer,

Ian M. Silverman,

Xinjun Ji,

Matthew R. Gazzara,

Nhu Nguyen,

Gabrielle Aguilar,

Massimo Martinelli,

Yoseph Barash,

Stephen A. Liebhaber

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00175-18

Subject(s) - biology , runx1 , exon , rna splicing , alternative splicing , gata1 , haematopoiesis , erythropoiesis , microbiology and biotechnology , genetics , stem cell , gene , rna , medicine , anemia

Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage.

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