MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway | Zendy

Mario Fernández-de Frutos | Zendy; Inmaculada Galán-Chilet | Zendy; Leigh Goedeke | Zendy; Byung-Wook Kim | Zendy; Virginia Pardo | Zendy; Ana Pérez-García | Zendy; J. Ignacio Herrero | Zendy; Carlos FernándezHernando | Zendy; Jungsu Kim | Zendy; Cristina M. Ramírez | Zendy

Open Access

MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway

Author(s) -

Mario Fernández-de Frutos,

Inmaculada Galán-Chilet,

Leigh Goedeke,

Byung-Wook Kim,

Virginia Pardo,

Ana Pérez-García,

J. Ignacio Herrero,

Carlos FernándezHernando,

Jungsu Kim,

Cristina M. Ramírez

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00170-19

Subject(s) - biology , insulin receptor , insulin degrading enzyme , irs2 , insulin , insulin resistance , endocrinology , insulin receptor substrate , medicine , irs1 , glucose homeostasis , downregulation and upregulation , microbiology and biotechnology , biochemistry , gene

Brain insulin resistance is a key pathological feature contributing to obesity, diabetes, and neurodegenerative disorders, including Alzheimer’s disease (AD). Besides the classic transcriptional mechanism mediated by hormones, posttranscriptional regulation has recently been shown to regulate a number of signaling pathways that could lead to metabolic diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research