The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin | Zendy

Alyssa Ward | Zendy; Gita Kumari | Zendy; Ranjan Sen | Zendy; Stephen Desiderio | Zendy

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The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin

Author(s) -

Alyssa Ward,

Gita Kumari,

Ranjan Sen,

Stephen Desiderio

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00159-18

Subject(s) - biology , extrachromosomal dna , chromatin , v(d)j recombination , genetics , recombinase , recombination signal sequences , h3k4me3 , point mutation , microbiology and biotechnology , locus (genetics) , mutation , recombination , gene , recombination activating gene , promoter , gene expression , genome

Accessibility of antigen receptor loci to RAG is correlated with the presence of H3K4me3, which binds to a plant homeodomain (PHD) in the RAG-2 subunit and promotes V(D)J recombination. A point mutation in the PHD, W453A, eliminates binding of H3K4me3 and impairs recombination.

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